Translational Research in Cardiovascular Repair

A critical look at cardiovascular translational research.

Clinical/Translational Research Sox2 Transduction Enhances Cardiovascular Repair Capacity of Blood-Derived Mesoangioblasts

Rationale: Complementation of pluripotency genes may improve adult stem cell functions. Objectives: Here we show that clonally expandable, telomerase expressing progenitor cells can be isolated from peripheral blood of children. The surface marker profile of the clonally expanded cells is distinct from hematopoietic or mesenchymal stromal cells, and resembles that of embryonic multipotent mesoa...

Translational Research in Peripheral Nerve Repair and Regeneration

The interest towards research in peripheral nerve repair regeneration has seen a great and progressive increase in the light of the continuous increase in the number of microsurgical nerve reconstructionsworldwide [1].While only few years ago nerve reconstruction was a rare type of surgery carried out in few high specialized centers only, it is becoming more and more frequent and widespread tod...

Microengineering in cardiovascular research: new developments and translational applications

Microfluidic, cellular co-cultures that approximate macro-scale biology are important tools for refining the in vitro study of organ-level function and disease. In recent years, advances in technical fabrication and biological integration have provided new insights into biological phenomena, improved diagnostic measurements, and made major steps towards de novo tissue creation. Here we review a...

Efficacy of Female Rat Models in Translational Cardiovascular Aging Research

Cardiovascular disease is the leading cause of death in women in the United States. Aging is a primary risk factor for the development of cardiovascular disease as well as cardiovascular-related morbidity and mortality. Aging is a universal process that all humans undergo; however, research in aging is limited by cost and time constraints. Therefore, most research in aging has been done in prim...